Xenogenetics in multifactorial disease susceptibility
Identifieur interne : 002213 ( Main/Exploration ); précédent : 002212; suivant : 002214Xenogenetics in multifactorial disease susceptibility
Auteurs : Edith Sim [Royaume-Uni] ; Lesley A. Stanley [Royaume-Uni] ; Angela Risch [Royaume-Uni] ; Peter Thygesen [Danemark]Source :
- Trends in Genetics [ 0168-9525 ] ; 1995.
Abstract
Susceptibility to multifactorial disease includes both genetic and environmental components. These two aspects of susceptibility are interlinked through genetic control of an individual's response to the environment. As a first step in identifying disease susceptibility genes that influence the response of an individual to foreign compounds (xenobiotics), it is necessary to study disorders in which there is an identified environmental trigger. Establishing a DNA resource from individuals with known environmental exposure (‘a xenogenetic register’) for diseases with an established environmental aetiology is an essential step in beginning to understand how environmental factors contribute to the susceptibility to polygenic diseases. A complementary approach to identification of environmental factors is suggested using a comparison of genetically homogeneous subdivisions of individuals with polygenic disease where there is no clue to the environmental trigger.
Url:
DOI: 10.1016/S0168-9525(00)89162-3
Affiliations:
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Stanley</name></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name></author><author><name sortKey="Thygesen, Peter" sort="Thygesen, Peter" uniqKey="Thygesen P" first="Peter" last="Thygesen">Peter Thygesen</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5B079E46C09C5E861F45138C29E924DFA2860204</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1016/S0168-9525(00)89162-3</idno><idno type="url">https://api.istex.fr/document/5B079E46C09C5E861F45138C29E924DFA2860204/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001F13</idno><idno type="wicri:Area/Main/Curation">001C20</idno><idno type="wicri:Area/Main/Exploration">002213</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Xenogenetics in multifactorial disease susceptibility</title><author><name sortKey="Sim, Edith" sort="Sim, Edith" uniqKey="Sim E" first="Edith" last="Sim">Edith Sim</name><affiliation wicri:level="4"><country>Royaume-Uni</country><wicri:regionArea>E. Sim, L.A. Stanley and A. Risch are in the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Stanley, Lesley A" sort="Stanley, Lesley A" uniqKey="Stanley L" first="Lesley A." last="Stanley">Lesley A. Stanley</name><affiliation wicri:level="4"><country>Royaume-Uni</country><wicri:regionArea>E. Sim, L.A. Stanley and A. Risch are in the Department of Pharmacology, University of Oxford, Mansfield Road, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation wicri:level="4"><country>Royaume-Uni</country><wicri:regionArea>E. Sim, L.A. Stanley and A. 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These two aspects of susceptibility are interlinked through genetic control of an individual's response to the environment. As a first step in identifying disease susceptibility genes that influence the response of an individual to foreign compounds (xenobiotics), it is necessary to study disorders in which there is an identified environmental trigger. Establishing a DNA resource from individuals with known environmental exposure (‘a xenogenetic register’) for diseases with an established environmental aetiology is an essential step in beginning to understand how environmental factors contribute to the susceptibility to polygenic diseases. 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Stanley</name></country><country name="Danemark"><noRegion><name sortKey="Thygesen, Peter" sort="Thygesen, Peter" uniqKey="Thygesen P" first="Peter" last="Thygesen">Peter Thygesen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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